All-in-One Longevity Supplements Compared (US)

Q: Is anything on the Build My Longevity supplements page medical advice?

No. It describes what is in each product and how strong the evidence is behind each ingredient, at a population level. It never recommends what someone specifically should take.

Q: Are these supplements FDA-approved?

No. Under the Dietary Supplement Health and Education Act of 1994 (DSHEA), the FDA does not approve dietary supplements before they are sold and generally does not approve their label claims. Companies are responsible for safety and for following FDA manufacturing rules, and the FDA can act against unsafe or mislabeled products once they are on the market. Advertising claims fall under the FTC, which expects health claims to be backed by competent and reliable scientific evidence.

Q: Are the stack breakdowns accurate?

Where a brand publishes a dosed ingredient panel, the tier counts are exact, checked against that panel on the brand's US site. Where a brand does not publish individual amounts, that is stated plainly and kept out of the counts. Doses are never estimated.

Q: Does any brand pay to be on the Build My Longevity supplements page?

No. No brand pays to be listed, and nothing a brand does can change its position or which tier an ingredient is placed in.

Side by side

Sort by any column. The evidence mix counts each product's dosed ingredients by tier: Tier 1 strong evidence, Tier 2 moderate, Tier 3 early. How we tier ingredients.

All-in-one longevity supplements sold in the US. Use the column heading buttons to sort.
				Evidence mix Tier 1 · 2 · 3
AG1 Next Gen	$69 90-day subscription	28 + 42 in undosed blends	None	23 · 5 · 0	NSF Certified for Sport®brand statement
Blueprint Longevity Mix	$49 30-day supply	11	None	2 · 6 · 3	None stated
DoNotAge® routine	$217.50 $203 per 4 weeks	15	1,000mg	3 · 4 · 8	Informed Sportbrand statement
IM8 Daily Ultimate Essentials Pro	$78.33 quarterly subscription	Not counted ~90 ingredients, many in blends	None	Not tiered too many to sort, see card	NSF Certified for Sport®brand statement

Prices are each brand's lowest price on its own US store, converted to 30 days where a brand bills in other cycles (DoNotAge® bills every 4 weeks; AG1's and IM8's lowest prices are on 90-day plans). Prices checked Oct 9, 2026. None of these products is FDA-approved: dietary supplements aren't approved by the FDA before sale (see the FAQ). Third-party testing is shown only as each brand states it. No brand pays to be listed or for its position.

What's inside each stack

Each product's ingredient panel, taken from the brand's own US site and sorted into the same three tiers. Where a brand doesn't publish individual amounts, we say so rather than guess.

AG1 Next Gen$79/mo subscription ($69/mo on 90-day plan; $99 one-off)

A greens, multivitamin and probiotic drink, sold in the US as AG1 Next Gen. Its dosed actives read more like a foundational daily-nutrition product than a "longevity" formula.

28 dosed actives, itemised from the US Supplement Facts panel, plus two undosed blends (see below)

23 · Tier 1

5 · Tier 2

Tier 2: CoQ10 60mg, Alpha-lipoic acid 100mg, Myo-inositol 100mg, Benfotiamine 25mg, Boron 500mcg. Tier 1: Vitamin C 500mg, Vitamin E 20mg, Vitamin B6 5mg, Zinc 20mg, Folate 680mcg DFE, Vitamin A 550mcg RAE, Vitamin B12 400mcg, Biotin 330mcg, Vitamin K2 90mcg, plus B1, B2, B3, B5, choline, calcium, iron, phosphorus, magnesium, selenium, copper, manganese, chromium and molybdenum, each with a stated amount on the panel. Sodium (35mg) and potassium (250mg) are listed but not counted as actives.

Not counted in the bar above: 42 plant, herb and mushroom ingredients (spirulina, ashwagandha, rhodiola, reishi, shiitake, milk thistle, grape seed extract and more) sit in two blends that state only a total weight (7.5g and 1.5g), with no individual amounts. There's also a 5-strain probiotic blend (37mg, 10 billion viable cells), which sits outside this page's 3 tiers. They're genuinely in the product, just not in amounts we can check or tier.

Benfotiamine (a form of vitamin B1) is filed in Tier 2 because the vitamin B1 need is already covered by the thiamin line. Billing: $79 every 30 days; $207 every 90 days ($69 per 30 days); or $99 one-off plus $9 shipping. The "$99" AG1 shows beside its subscription prices is its own one-off comparison, not a former price. Third-party testing: AG1 states "NSF Certified for Sport®". We haven't checked NSF's own listing. Supplement Facts (US page) · ingredients checked Oct 10, 2026 · price checked Oct 9, 2026

Brand sitedrinkag1.com ↗

Blueprint Longevity Mix$49 / 30 days

From Bryan Johnson's company Blueprint (his own protocol is profiled on our Thought leaders page). A drink mix: $49 for a 30-day supply or $147 for 90 days.

11 dosed actives, fully itemised from the US Supplement Facts panel

2 · Tier 1

6 · Tier 2

3 · Tier 3

Tier 3: Calcium alpha-ketoglutarate (Ca-AKG) 2,000mg, L-glutathione 250mg, Sodium hyaluronate 120mg. Tier 2: Creatine 2,500mg, Taurine 1,500mg, Glycine 1,200mg, L-lysine 1,000mg, Glucosamine sulfate 750mg, L-theanine 200mg. Tier 1: Vitamin C 250mg, Magnesium 150mg.

The only stack here with no NAD+ precursor (no NMN or NR). Its largest share is Tier 2, led by 2.5g of creatine, taurine and glycine. The panel lists 400mg of calcium, but that's the calcium carried by the 2g of Ca-AKG, so it isn't counted separately (Blueprint itself says "12 longevity actives" because it counts calcium). Blueprint's US product data didn't show a subscription discount, so check at checkout. Third-party testing: None stated on the product page we checked. Supplement Facts · ingredients checked Oct 9, 2026 · price checked Oct 9, 2026

Brand siteblueprint.bryanjohnson.com ↗

DoNotAge® routine$203 per 4 weeks

DoNotAge's flagship all-in-one sachet routine, a separate product from its standalone NMN capsules. Sold on a subscription billed every 4 weeks ($203 per cycle, $7.25 per serving).

15 dosed actives, fully itemised from the nutritional-information graphic on the US page

3 · Tier 1

4 · Tier 2

8 · Tier 3

Tier 3: SIRT6Activator® 1,600mg, Pure NMN 1,000mg, Ca-AKG 800mg, Trans-resveratrol 500mg, Quercetin 400mg, SulforaBoost® 230mg, High molecular weight hyaluronic acid 200mg, Spermidine 8mg. Tier 2: Glycine 2,000mg, TMG 1,000mg, Nitralis® 400mg, CoQ10 200mg. Tier 1: Magnesium bisglycinate 250mg, Vitamin K2 (MK-7) 120mcg, Vitamin D3 125mcg.

The most Tier 3-heavy stack here: over half its dosed actives target a specific aging pathway with early human evidence. Three ingredients (SIRT6Activator®, Nitralis®, SulforaBoost®) are DoNotAge's own branded compounds; their exact composition isn't disclosed, so they're filed by the mechanism DoNotAge states. The panel is a brand graphic, not a formal Supplement Facts panel. DoNotAge says this routine was tested in a placebo-controlled trial (citing a 76% average NAD+ increase); those are its own figures, which we haven't verified against a publication. The $683 it shows struck through is its "compared to buying individually" figure, not a former price. Third-party testing: DoNotAge states "Informed Sport certified" and that "Certification is granted batch by batch". We haven't checked the Informed Sport register. Nutritional information (US page) · ingredients checked Oct 9, 2026 · price checked Oct 9, 2026

Brand siteroutine.donotage.org ↗

IM8 Daily Ultimate Essentials Pro$89/mo subscription ($112 one-off)

About 90 ingredients in one drink. $89 a month on subscription, $235 a quarter (about $78.33 per 30 days) or $112 one-off.

Too large and mixed to sort usefully into 3 tiers, so we're saying so rather than forcing a number. On the US Supplement Facts panel, the vitamins and minerals (26 lines, including sodium and potassium) each have a stated amount, as do MSM 1,500mg, CoQ10 100mg and saffron 30mg. Everything else sits in complexes that give only a total weight: Raw Superfoods & Greens 4,100mg · Hydra Electrolytes 2,500mg · Essential Amino & Renew 1,580mg · Enzymes, Adaptogens & Mushrooms 200mg · CRT8 100mg (including trans-resveratrol, berberine and spermidine) · Probiotics 84mg (10 billion CFU) · Postbiotics 25mg.

Vitamins & mineralsSuperfoods & greensElectrolytesAmino & RenewEnzymes & mushroomsCRT8ProbioticsPostbiotics

One concrete find from the panel: it contains vitamin B6 at 5mg (294% of the Daily Value). That's the kind of ingredient our guide flags: a vitamin most people already get elsewhere can add up to more than intended when you take several supplements at once.

IM8 has no NMN on its panel. The CRT8 complex names spermidine and resveratrol but doesn't give their individual amounts. Third-party testing: IM8 states that every ingredient is "third-party tested and NSF Certified for Sport". We haven't checked NSF's own listing. Supplement Facts (US page) · ingredients checked Oct 9, 2026 · price checked Oct 9, 2026

Brand siteim8health.com ↗

Straight answers, sourced

Is anything on this page medical advice?

No. This page describes what's in each product and how strong the evidence is behind each ingredient, at a population level. It never recommends what you specifically should take. A doctor who knows your health and your own lab results can tell you whether a supplement suits you in a way a general page can't; see our guide.

Are these supplements FDA-approved?

No, and none of them could be. Under the Dietary Supplement Health and Education Act of 1994 (DSHEA), the FDA doesn't approve dietary supplements before they're sold, and it generally doesn't approve their label claims either. Companies are responsible for their products' safety and for following the FDA's manufacturing rules, and the FDA can act against unsafe or mislabeled products once they're on the market. Advertising claims fall under the FTC, which expects health claims to be backed by "competent and reliable scientific evidence". So "FDA-approved" on a supplement would be a red flag, and a brand's health claims are its own, not the FDA's. FDA: Questions and answers on dietary supplements · FTC: Health Products Compliance Guidance · checked Oct 10, 2026.

What does "third-party testing" mean here?

Some brands pay an independent program to test batches, for example for banned substances or contaminants. The column shows only what each brand states on its own US product page: NSF Certified for Sport (AG1 and IM8) or Informed Sport (DoNotAge®). We haven't checked the certifiers' own listings yet, and a certification isn't evidence that a product works. "None stated" means we didn't see a certification claim on the page we checked.

How are ingredients sorted into tiers?

By the strength of the human evidence behind each ingredient, not popularity or price: Tier 1 fills a common nutrient gap with strong, replicated evidence; Tier 2 has moderate evidence; Tier 3 targets a specific aging pathway with early evidence. The full method, with each ingredient explained, is on the supplement evidence page.

Are the stack breakdowns accurate?

Where a brand publishes a dosed ingredient panel (AG1 Next Gen, Blueprint Longevity Mix, DoNotAge® routine), the tier counts are exact, checked against that panel on the brand's US site. Where a brand doesn't publish individual amounts (AG1's two blends, most of IM8's formula), we say so and keep those ingredients out of the counts. We never estimate a dose.

Does any brand pay to be on this page?

No. No brand pays to be listed here, and nothing a brand does can change its position or which tier an ingredient sits in.

Side by side

What's inside each stack

Straight answers, sourced

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